Artikel
Open Access (CC BY-SA 4.0)
Peer Reviewed
The relationship between the length of treatment for pulmonary tuberculosis patients in the intensive phase and hemoglobin levels
Article Publication History
Received
16 Jul 2024
Revised
24 Oct 2024
Accepted
24 Oct 2024
Published Online
25 Oct 2024
Abstract
Background: Tuberculosis (TB) medication can alter hematological parameters, including hemoglobin levels. Hemoglobin levels due to anti-TB drugs have the potential to cause anemia. Therefore, it is important to know the risk of anemia during intensive phase TB treatment therapy. Objectives: This study aims to determine the relationship between the length of treatment for TB patients in the intensive phase and hemoglobin levels. Materials and Methods: The sample was selected using the accidental sampling method. The number of samples obtained was 31 consisting of 17 respondents from the Kedungmundu Community Health Center, 14 respondents from the Bangetayu Community Health Center. EDTA blood was analyzed using a KX21-N hematology analyzer. The relationship between the duration of treatment and hemoglobin levels in TB patients was statistically tested using Pearson correlation test. Results: Most of the intensive phase TB patients are in the 15-24 years age group. The percentage of female patients is 54.8%, and 45.2% male. TB patients with a treatment duration of 5-8 weeks are 34.1% and a treatment duration of 1-4 weeks is 65.9%. Normal hemoglobin levels are 51.6%, and low hemoglobin levels are 48.4%. The results of the Pearson correlation test have a significance level of 0.862. Conclusion: There is no correlation between the duration of treatment of intensive phase TB patients and hemoglobin levels. The importance of monitoring hemoglobin levels during intensive phase treatment, in order to monitor the effectiveness of treatment or the presence of complications such as anemia.
References
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Shadrina, A. N., & Atikah, T. (2019). Haemoglobin Level and Nutritional Status Changes Among Under-Five Children Treated with Antituberculosis Therapy in Cirebon. Asia Pacific Journal of Pediatrics and Child Health (APJPCH), 2(Juli-September), 43–51. https://apjpch.com/pdfs/19924mbo132022.pdf
Shah, A. R., Desai, K. N., & Maru, A. M. (2022). Evaluation of Hematological Parameters in Pulmonary Tuberculosis Patients. Journal of Family Medicine and Primary Care, 11(8), 4424–4428. https://doi.org/10.4103/jfmpc.jfmpc_2451_21
Sheetal, M. R, M., & Rub Patwegar, A. (2020). Comparative Study of Hematological Parameters in Newly Diagnosed Tuberculosis Patient’s Pre-ATT & After Intensive Phase of ATT. IP Archives of Cytology and Histopathology Research, 3(4), 185–191. https://doi.org/10.18231/2456-9267.2018.0038
Situmorang, P. R. (2020). Kadar Hemoglobin Penderita Tuberkulosis Paru Yang Menjalankan Terapi Obat Anti Tuberkulosis Di Puskesmas Pancur Batu Kabupaten Deli Serdang 2019. Elisabeth Health Jurnal, 5(02), 72–79. https://doi.org/10.52317/ehj.v5i02.313
Ulfah, U. (2022). Gambaran Kadar Asam Urat Pada Penderita Tuberkulosis Paru Yang Mengkonsumsi Obat Anti Tuberkulosis (OAT). Jurnal Kesehatan Rajawali, 11(2), 40–45. https://doi.org/10.54350/jkr.v11i2.108
World Health Organization. (2020). Tuberculosis Report. In Baltimore Health News: Vol. XLIX (Issues 9-10–11).
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Berliana, N., Listiawaty, R., & Prasetyo, H. (2020). Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Minum Obat Penderita Tb Paru Di Wilayah Kerja Puskesmas Nipah Panjang Tahun 2019. Journal of Chemical Information and Modeling, 53(9), 1689–1699. https://jurnal.ikbis.ac.id/index.php/infokes/article/view/124/62
Bonsome, B. (2017). Evaluation of Haematological Parameters in the Initial Phase of Anti-Tuberculosis Therapy in Yenagoa, Nigeria. Niger Delta Medical Journal, 1(4), 10–15. http://ndmjournal.org/wp-content/uploads/2018/03/Evaluation-of-haematological-parameters-in-the-initial-phase.pdf
Booth, K. A., & Mundt, L. (2019). Phlebotomy A Competency-Based Approach. In Angewandte Chemie International Edition, 6(11), 951–952. (Fifth, Vol. 3, Issue 1). McGraw-Hill Education.
Corporation, S. (2014). Operator’s Manual Sysmex KX-21 (Issue 461). https://5.imimg.com/data5/OF/YZ/FH/SELLER-4426370/sysmax-kx-21.pdf
Dabbagh, D. Al. (2009). Practical Haematology. Clinical Laboratory Scientist USA.
Dinas Kesehatan Kota Semarang. (2022a). Dasbord Kesehatan Dinkes Kota Semarang 2022.pdf. Dinas Kesehatan. http://119.2.50.170:9095/dashboardNew/
Dinas Kesehatan Kota Semarang. (2022b). Profil Kesehatan Kota Semarang 2022. In Dinas Kesehatan Kota Semarang (Vol. 6, Issue 1). https://pustakadata.semarangkota.go.id/public/upload/pdf/451-profil-kesehatan-2022.pdf
Dinas Kesehatan Provinsi Jateng. (2022). Profil Dinas Kesehatan Jawa Tengah 2022. In Profil Kesehatan Jawa Tengah. https://dinkesjatengprov.go.id/v2018/dokumen/Buku_Profil_Kesehatan_2022/mobile/index.html
Fayed, H. M., Mohammed, A. E., Badawy, M. S., & Yassin, A. S. (2018). The Utility and Validity of Immunological, Inflammatory, and Nutritional-based Scores and Indices in Active Pulmonary Tuberculosis. International Clinical Pathology Journal, 6(6), 199–213. https://doi.org/10.15406/icpjl.2018.06.00188
Greer, J. P., Rodgers, G. M., Arber, D. A., & Means, R. T. (2019). Wintrobe’s Clinical Hematology (J. P. Greer (ed.); Fourteenth). Wolters Kluwer. https://doi.org/10.1016/b978-012396305-5/50008-7
Kahar, F., Wikandari, R. J., Irnawati, I., & Penmaley, M. S. (2022). The Effect of Cigarette Smoking Duration on Hemoglobin Level Measured with Cyanmethemoglobin Method. Indonesian Journal of Medical Laboratory Science and Technology, 4(2), 157–167. https://doi.org/10.33086/ijmlst.v4i2.2674
Kassa, E., Enawgaw, B., Gelaw, A., & Gelaw, B. (2016). Effect of anti-tuberculosis drugs on hematological profiles of tuberculosis patients attending at University of Gondar Hospital, Northwest Ethiopia. BMC Hematology, 16(1), 2–11. https://doi.org/10.1186/s12878-015-0037-1
Kementerian Kesehatan RI. (2018). Pedoman Pencegahan Penanggulangan Anemia Pada Remaja Putri dan Wanita Usia Subur.
Kementerian Kesehatan RI. (2023). Profil Kesehatan Indonesia Tahun 2022. https://kemkes.go.id/id/profil-kesehatan-indonesia-2022
Kenzie, S. B. M., & Williams, J. L. (2015). Clinical Laboratory Haematology. In K. L. Piwowar (Ed.), Clinical Laboratory Hematology (Third, Vol. 16, Issue 2). Pearson Education, INc.
Maulidiyanti, E. T. S. (2020). Status Kadar Hemoglobin Dan Jenis Leukosit Pada Pasien TB Paru Di Surabaya. The Journal of Muhammadiyah Medical Laboratory Technologist, 3(1), 53. https://doi.org/10.30651/jmlt.v3i1.4013
Mursalim, Djasang, S., Nuradi, & Hadijah, S. (2022). Kadar Hemoglobin Pada Penderita Tuberkulosis Paru Yang Mengkonsumsi Obat Anti Tuberkulosis. Jurnal Media Analis Kesehatan, 12(1), 64–70. https://doi.org/https://doi.org/10.32382/mak.v13i1.2765
Permana, A. (2020). Gambaran Kadar Hemoglobin(Hb) Dan Leukosit Pada Penderita Tb Paru Dengan Lamanya Terapi OAT (Obat Anti Tuberculosis) Di Rumah Sakit Islam Jakarta Cempaka. Anakes?: Jurnal Ilmiah Analis Kesehatan, 6(2), 136–143. https://doi.org/10.37012/anakes.v6i2.364
Purba, S. K. R. (2021). Pemeriksaan Kadar Hemoglobin pada Pasien Penderita Tuberkulosis Paru di RSUP. H. Adam Malik Medan. Journal of Medical Laboratory, 2(1), 1–5. https://ijml.jurnalsenior.com/index.php/ijml/article/view/12
Rojali, R., & Noviatuzzahrah, N. (2018). Faktor Risiko Kepatuhan Pengobatan pada Penderita Tb Paru BTA Positif. Jurnal Kesehatan, 9(1), 70. https://doi.org/10.26630/jk.v9i1.754
Saxena, R., Chamoli, S., & Batra, M. (2018). Clinical Evaluation of Different Types of Anemia. World Journal of Anemia, 2(1), 26–30. https://doi.org/10.5005/jp-journals-10065-0024
Sazali, M. F., Rahim, S. S. S. A., Mohammad, A. H., Kadir, F., Payus, A. O., Avoi, R., Jeffree, M. S., Omar, A., Ibrahim, M. Y., Atil, A., Tuah, N. M., Dapari, R., Lansing, M. G., Rahim, A. A. A., & Azhar, Z. I. (2023). Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model. Tuberculosis and Respiratory Diseases, 86(2), 82–93. https://doi.org/10.4046/trd.2022.0148
Shadrina, A. N., & Atikah, T. (2019). Haemoglobin Level and Nutritional Status Changes Among Under-Five Children Treated with Antituberculosis Therapy in Cirebon. Asia Pacific Journal of Pediatrics and Child Health (APJPCH), 2(Juli-September), 43–51. https://apjpch.com/pdfs/19924mbo132022.pdf
Shah, A. R., Desai, K. N., & Maru, A. M. (2022). Evaluation of Hematological Parameters in Pulmonary Tuberculosis Patients. Journal of Family Medicine and Primary Care, 11(8), 4424–4428. https://doi.org/10.4103/jfmpc.jfmpc_2451_21
Sheetal, M. R, M., & Rub Patwegar, A. (2020). Comparative Study of Hematological Parameters in Newly Diagnosed Tuberculosis Patient’s Pre-ATT & After Intensive Phase of ATT. IP Archives of Cytology and Histopathology Research, 3(4), 185–191. https://doi.org/10.18231/2456-9267.2018.0038
Situmorang, P. R. (2020). Kadar Hemoglobin Penderita Tuberkulosis Paru Yang Menjalankan Terapi Obat Anti Tuberkulosis Di Puskesmas Pancur Batu Kabupaten Deli Serdang 2019. Elisabeth Health Jurnal, 5(02), 72–79. https://doi.org/10.52317/ehj.v5i02.313
Ulfah, U. (2022). Gambaran Kadar Asam Urat Pada Penderita Tuberkulosis Paru Yang Mengkonsumsi Obat Anti Tuberkulosis (OAT). Jurnal Kesehatan Rajawali, 11(2), 40–45. https://doi.org/10.54350/jkr.v11i2.108
World Health Organization. (2020). Tuberculosis Report. In Baltimore Health News: Vol. XLIX (Issues 9-10–11).
World Health Organization, (WHO). (2023). Global Tuberculosis Report 2023. In January. https://iris.who.int/